nitroimidazoles iv [i]. synthesis of 3,s-dicarbo alkoxy-2,6-dimethyl-4-(1 -methyl-5- nitro-2-1midazolyl)-1,4-dihydropyridianne d 3,5-dicarboalkoxy- 2,6-dimethyl-4(-2 -s ubsti - tuted-4-thiazolyl)-l , 4- dihydropyridine
نویسندگان
چکیده
different procedures for the syntheses of the title compounds were investigated. the best method for the preparation of the title compounds were the reaction of the readily available 2-formyl-1-methyl-5-nitroimidazole2- substituted-4-formylthiazoles with alkyl acetoacetate and alkyl aminocrotonate in boiling alcohol.
منابع مشابه
NITROIMIDAZOLES IV [I]. SYNTHESIS OF 3,s-DICARBO ALKOXY-2,6-DIMETHYL-4-(1 -METHYL-5- NITRO-2-1MIDAZOLYL)-1,4-DIHYDROPYRIDIANNE D 3,5-DICARBOALKOXY- 2,6-DIMETHYL-4(-2 -S UBSTI - TUTED-4-THIAZOLYL)-l , 4- DIHYDROPYRIDINE
Different procedures for the syntheses of the title compounds were investigated. The best method for the preparation of the title compounds were the reaction of the readily available 2-formyL-1-methyl-5-nitroimidazole2- substituted-4-formylthiazoles with alkyl acetoacetate and alkyl aminocrotonate in boiling alcohol.
متن کاملDesign and Synthesis of 2-Methyl and 2-Methyl-4-Nitro Imidazole Derivatives as Antifungal Agents
Two series (a and b) of N- substituted heteroaromatic compounds related to clotrimazole were synthesized. Imidazole ring of the clotrimazole was replaced by 2-methylimidazole in series a, and by 2-methyl-4-nitroimidazole in series b. O-cholortrityl moiety of clotrimazole was also replaced by trityl, mono or dimethoxy trityl. Chemical structures...
متن کاملDimethyl 4-ethoxy-1-(4-methyl-2-pyridyl)-5-oxo-2,5-dihydro-1H-pyrrole-2,3-dicarboxylate
In the title compound, C(16)H(18)N(2)O(6), the dihedral angle between the aromatic ring planes is 8.11 (6)°. One of the O atoms is disordered over two sites of equal occupancy. In the crystal structure, aromatic π-π stacking [centroid-to-centroid separation = 3.5503 (8) Å] helps to consolidate the packing.
متن کاملSynthesis and Antimicrobial Activity of Some 2-[(4-Substituted-Phenyl-3-Chloro-Azetidin-2-One)-5-(2'-Methylamino-4-Phenyl-1', 3'-Thiazolyl-]-1, 3,4-Thiadiazoles
A new 2-[(4-substituted-phenyl-3-chloroazetidin-2-one)-5-(2'-methylamino 4-phenyl-1', 3'-thiazolyl-]-1, 3, 4-thiadiazoles, 5(a-n) were synthesized from 2-substituted-benzylideneamino-5-[2'-methylamino-4'-phenyl-1',3'-thiazolyl]-1,3, 4-thiadiazole, 4(a-n) using 2-amino-4phenyl-1, 3-thiazole as a starting material. The synthesised compounds have been screened in vitro for their antimicrobial acti...
متن کامل7,7-Dimethyl-2-methylamino-4-(4-methylphenyl)-3-nitro-7,8-dihydro-4H-chromen-5(6H)-one
In the title compound, C19H22N2O4, the six-membered cyclo-hexenone ring of the chromene unit adopts an envelope conformation, with the dimethyl-substituted C atom as the flap, while the pyran ring has a boat conformation. These two mean planes are inclined to one another by 6.65 (13)°·The benzene ring is normal to the 4H-chromene moiety mean plane, making a dihedral angle of 89.18 (5)°. The met...
متن کاملSynthesis and Leishmanicidal Activity of 1-[5-(5-nitrofuran-2-yl)-1, 3, 4-thiadiazole-2-yl]-4-benzoylepiperazines
A series of (5-nitrofuran-2-yl)-1, 3, 4-thiadiazole-2-yl derivatives 6a–6e have been synthesized and screened for in vitro anti-leishmanial activity against the promastigote form of L. major. The structure of Schiff bases were confirmed by 1H NMR, IR. Screening results indicate that all of the designed and synthesized final compounds (6a-6e) significantly reduced the viability of promastigotes ...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
journal of sciences islamic republic of iranجلد ۱، شماره ۱، صفحات ۰-۰
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023